Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect
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چکیده
منابع مشابه
Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect.
AIMS To determine whether trimetazidine (TMZ) improves the endothelium-dependent relaxation (EDR) in chronic heart failure (CHF) and whether this effect is associated with its antioxidant properties. METHODS AND RESULTS We studied 51 patients (mean age 51.4 +/- 6 years) with CHF secondary to ischaemic cardiomyopathy (ejection fraction 32.5 +/- 4.5%). Plasma malondialdehyde (MDA) and lipid hyd...
متن کاملAllopurinol improves endothelial dysfunction in chronic heart failure.
BACKGROUND Increased oxidative stress in chronic heart failure is thought to contribute to endothelial dysfunction. Xanthine oxidase produces oxidative stress and therefore we examined whether allopurinol improved endothelial dysfunction in chronic heart failure. METHODS AND RESULTS We performed a randomized, placebo-controlled, double-blind crossover study on 11 patients with New York Heart ...
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Endothelial dysfunction crucially contributes to the development of impaired coronary and systemic perfusion as well as reduced exercise capacity in patients with congestive heart failure, with fundamental impact on morbidity and mortality. Reduced bioavailability of nitric oxide (NO) and abundant formation of reactive oxygen species (ROS) within the vascular wall are the key determinants in en...
متن کامل[Inflammation and endothelial dysfunction in patients with chronic heart failure].
BACKGROUND In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. AIM To assess the association between inflammation and ED in CHF. MATERIAL AND METHODS Forty two patients aged 56+/-14 years (80% male) with a CHF in functional capacity ...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2007
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehm071